Managing Alpha-1 Antitrypsin Deficiency with Prolastin
What Is Prolastin and How Does It Work?
Prolastin is a medication made from donated human plasma. It replaces a missing protein in your body called alpha-1 antitrypsin (AAT).
AAT helps protect your lungs from damage
People with Alpha-1 deficiency do not have enough AAT
Prolastin raises your AAT level to help slow lung damage over time
Prolastin does not cure Alpha-1 deficiency and will not reverse lung damage, but it helps protect your lungs from further harm.
What to Expect During Your Infusion
Prolastin is given through an IV (vein)
Infusions usually take 15–20 minutes
Most patients receive treatment once a week
You will be monitored during and after your infusion
Common Side Effects (After Infusion)
These may occur later the same day or within a few days:
Tiredness
Muscle or joint aches
Headache
Mild flu-like symptoms
Lifestyle Choices That Help Your Treatment Work Better
Avoid Smoking
Smoking causes major lung damage
Even secondhand smoke can reduce the benefit of Prolastin®
Protect Your Lungs
Avoid dust, fumes, and chemical irritants
Wear masks if needed at work or during cleaning
Stay Up to Date on Vaccines
Flu vaccine (yearly)
Pneumonia vaccines as recommended
COVID-19 vaccines if advised by your provider
Stay Hydrated
Drinking water can help reduce headaches and fatigue after infusions
Stay Active (as able)
Gentle exercise can improve breathing and overall health
Pulmonary rehab may be helpful
Keep Regular Appointments
Attend all scheduled infusions
Follow up with your lung specialist regularly
Important for Families
Alpha-1 Antitrypsin Deficiency is genetic.
Family members should be tested for the Alpha-1 gene so they can understand their own risk and receive care if needed